Genetics of autoimmunity in plants: an evolutionary genetics perspective.
Identifieur interne : 000145 ( Main/Exploration ); précédent : 000144; suivant : 000146Genetics of autoimmunity in plants: an evolutionary genetics perspective.
Auteurs : Wei-Lin Wan [Singapour] ; Sang-Tae Kim [Corée du Sud] ; Baptiste Castel [Singapour] ; Nuri Charoennit [Singapour] ; Eunyoung Chae [Singapour]Source :
- The New phytologist [ 1469-8137 ] ; 2020.
Abstract
Autoimmunity in plants has been found in numerous hybrids as a form of hybrid necrosis and mutant panels. Uncontrolled cell death is a main cellular outcome of autoimmunity, which negatively impacts growth. Its occurrence highlights the vulnerable nature of the plant immune system. Genetic investigation of autoimmunity in hybrid plants revealed that extreme variation in the immune receptor repertoire is a major contributor, reflecting an evolutionary conundrum that plants face in nature. In this review, we discuss natural variation in the plant immune system and its contribution to fitness. The value of autoimmunity genetics lies in its ability to identify combinations of a natural immune receptor and its partner that are predisposed to triggering autoimmunity. The network of immune components for autoimmunity becomes instrumental in revealing mechanistic details of how immune receptors recognize cellular invasion and activate signaling. The list of autoimmunity-risk variants also allows us to infer evolutionary processes contributing to their maintenance in the natural population. Our approach to autoimmunity, which integrates mechanistic understanding and evolutionary genetics, has the potential to serve as a prognosis tool to optimize immunity in crops.
DOI: 10.1111/nph.16947
PubMed: 32970825
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of Singapore, Singapore, 117558</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Kim, Sang Tae" sort="Kim, Sang Tae" uniqKey="Kim S" first="Sang-Tae" last="Kim">Sang-Tae Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Life Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662</wicri:regionArea><wicri:noRegion>14662</wicri:noRegion></affiliation></author><author><name sortKey="Castel, Baptiste" sort="Castel, Baptiste" uniqKey="Castel B" first="Baptiste" last="Castel">Baptiste Castel</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Biological Sciences, National University of Singapore, Singapore, 117558</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Charoennit, Nuri" sort="Charoennit, Nuri" uniqKey="Charoennit N" first="Nuri" last="Charoennit">Nuri Charoennit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Biological Sciences, National University of Singapore, Singapore, 117558</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Chae, Eunyoung" sort="Chae, Eunyoung" uniqKey="Chae E" first="Eunyoung" last="Chae">Eunyoung Chae</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Biological Sciences, National University of Singapore, Singapore, 117558</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author></analytic><series><title level="j">The New phytologist</title><idno type="eISSN">1469-8137</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autoimmunity in plants has been found in numerous hybrids as a form of hybrid necrosis and mutant panels. Uncontrolled cell death is a main cellular outcome of autoimmunity, which negatively impacts growth. Its occurrence highlights the vulnerable nature of the plant immune system. Genetic investigation of autoimmunity in hybrid plants revealed that extreme variation in the immune receptor repertoire is a major contributor, reflecting an evolutionary conundrum that plants face in nature. In this review, we discuss natural variation in the plant immune system and its contribution to fitness. The value of autoimmunity genetics lies in its ability to identify combinations of a natural immune receptor and its partner that are predisposed to triggering autoimmunity. The network of immune components for autoimmunity becomes instrumental in revealing mechanistic details of how immune receptors recognize cellular invasion and activate signaling. The list of autoimmunity-risk variants also allows us to infer evolutionary processes contributing to their maintenance in the natural population. Our approach to autoimmunity, which integrates mechanistic understanding and evolutionary genetics, has the potential to serve as a prognosis tool to optimize immunity in crops.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32970825</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-8137</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Sep</Month><Day>24</Day></PubDate></JournalIssue><Title>The New phytologist</Title><ISOAbbreviation>New Phytol</ISOAbbreviation></Journal><ArticleTitle>Genetics of autoimmunity in plants: an evolutionary genetics perspective.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/nph.16947</ELocationID><Abstract><AbstractText>Autoimmunity in plants has been found in numerous hybrids as a form of hybrid necrosis and mutant panels. Uncontrolled cell death is a main cellular outcome of autoimmunity, which negatively impacts growth. Its occurrence highlights the vulnerable nature of the plant immune system. Genetic investigation of autoimmunity in hybrid plants revealed that extreme variation in the immune receptor repertoire is a major contributor, reflecting an evolutionary conundrum that plants face in nature. In this review, we discuss natural variation in the plant immune system and its contribution to fitness. The value of autoimmunity genetics lies in its ability to identify combinations of a natural immune receptor and its partner that are predisposed to triggering autoimmunity. The network of immune components for autoimmunity becomes instrumental in revealing mechanistic details of how immune receptors recognize cellular invasion and activate signaling. The list of autoimmunity-risk variants also allows us to infer evolutionary processes contributing to their maintenance in the natural population. Our approach to autoimmunity, which integrates mechanistic understanding and evolutionary genetics, has the potential to serve as a prognosis tool to optimize immunity in crops.</AbstractText><CopyrightInformation>© 2020 The Authors. New Phytologist © 2020 New Phytologist Foundation.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Wei-Lin</ForeName><Initials>WL</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2062-8466</Identifier><AffiliationInfo><Affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Sang-Tae</ForeName><Initials>ST</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1645-6021</Identifier><AffiliationInfo><Affiliation>Department of Life Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, 14662, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castel</LastName><ForeName>Baptiste</ForeName><Initials>B</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2722-0228</Identifier><AffiliationInfo><Affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charoennit</LastName><ForeName>Nuri</ForeName><Initials>N</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2210-4615</Identifier><AffiliationInfo><Affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chae</LastName><ForeName>Eunyoung</ForeName><Initials>E</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0889-9837</Identifier><AffiliationInfo><Affiliation>Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MOE2019-T2-1-134</GrantID><Agency>Ministry of Education, Singapore</Agency><Country></Country></Grant><Grant><GrantID>R-154-000-B20-114</GrantID><Agency>National University of Singapore</Agency><Country></Country></Grant><Grant><GrantID>R-154-000-B33-114</GrantID><Agency>National University of Singapore</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>New Phytol</MedlineTA><NlmUniqueID>9882884</NlmUniqueID><ISSNLinking>0028-646X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">NLR</Keyword><Keyword MajorTopicYN="N">autoimmunity</Keyword><Keyword MajorTopicYN="N">cell death</Keyword><Keyword MajorTopicYN="N">epistasis</Keyword><Keyword MajorTopicYN="N">genetic incompatibility</Keyword><Keyword MajorTopicYN="N">guardee</Keyword><Keyword MajorTopicYN="N">hybrid necrosis</Keyword><Keyword MajorTopicYN="N">plant immunity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>24</Day><Hour>17</Hour><Minute>15</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32970825</ArticleId><ArticleId IdType="doi">10.1111/nph.16947</ArticleId></ArticleIdList><ReferenceList><Title>References</Title><Reference><Citation>Adachi H, Derevnina L, Kamoun S. 2019. 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PLoS Genetics 14: e1007628.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Wan, Wei Lin" sort="Wan, Wei Lin" uniqKey="Wan W" first="Wei-Lin" last="Wan">Wei-Lin Wan</name></noRegion><name sortKey="Castel, Baptiste" sort="Castel, Baptiste" uniqKey="Castel B" first="Baptiste" last="Castel">Baptiste Castel</name><name sortKey="Chae, Eunyoung" sort="Chae, Eunyoung" uniqKey="Chae E" first="Eunyoung" last="Chae">Eunyoung Chae</name><name sortKey="Charoennit, Nuri" sort="Charoennit, Nuri" uniqKey="Charoennit N" first="Nuri" last="Charoennit">Nuri Charoennit</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kim, Sang Tae" sort="Kim, Sang Tae" uniqKey="Kim S" first="Sang-Tae" last="Kim">Sang-Tae Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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